翻訳と辞書 Words near each other ・ Discovery and development of direct thrombin inhibitors ・ Discovery and development of gliflozins ・ Discovery and development of HIV-protease inhibitors ・ Discovery and development of integrase inhibitors ・ Discovery and development of matrix metalloproteinase inhibitors ・ Discovery and development of memantine and related compounds ・ Discovery and development of neuraminidase inhibitors ・ Discovery and development of non-nucleoside reverse-transcriptase inhibitors ・ Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors ・ Discovery and development of phosphodiesterase 5 inhibitors ・ Discovery and development of proton pump inhibitors ・ Discovery and development of statins ・ Discovery and development of steroidal aromatase inhibitors ・ Discovery and development of triptans ・ Discovery and development of TRPV1 antagonists ・ Discovery and development of tubulin inhibitors ・ Discovery and exploration of the Solar System ・ Discovery and Launch ・ Discovery Arcade (Disneyland Paris) ・ Discovery Atlas ・ Discovery Aviation Model 201 ・ Discovery Bay ・ Discovery Bay (Antarctica) ・ Discovery Bay (Australia) ・ Discovery Bay (disambiguation) ・ Discovery Bay Coastal Park ・ Discovery Bay Ferry Pier ・ Discovery Bay International School ・ Discovery Bay Marine National Park ・ Discovery Bay Transportation Services Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Discovery and development of tubulin inhibitors ： ウィキペディア英語版 Discovery and development of tubulin inhibitors Tubulin inhibitors are drugs that interfere directly with the tubulin system, which is in contrast to those drugs acting on DNA for cancer chemotherapy. Microtubules play an important role in eukaryotic cells. Alpha- and beta-tubulin, the main components of microtubules, have gained considerable interest because of their function and biophysical properties and has become the subject of intense study. The addition of tubulin ligands can affect microtubule stability and function, including mitosis, cell motion and intracellular organelle transport. Tubulin binding molecules have generated significant interest after the introduction of the taxanes into clinical oncology and the general use of the vinca alkaloids. These compounds inhibit cell mitosis by binding to the protein tubulin in the mitotic spindle and preventing polymerization or depolymerization into the microtubules. This mode of action is also shared with another natural agent called colchicine. == History == The first known compound which binds to tubulin was colchicine, it was isolated from the autumn crocus, ''Colchicum autumnale'', but it has not been used for cancer treatment. First anticancer drugs approved for clinical use were Vinca alkaloids, vinblastine and vincristine in the 1960s. They were isolated from extracts leaves of the ''Catharanthus roseus'' (''Vinca rosea'') plant at the University of Western Ontario in 1958. First drug belong to the taxanes and paclitaxel, discovered in extracts from the bark of the yew tree, ''Taxus brevifolia'', in 1967 by Monroe Wall and Mansukh Wani but, its tubulin inhibition activity was not known until 1979. Yews trees are poor source of active agents what limited the development of taxanes for over 20 years until discover the way of synthesis.〔 In December 1992 paclitaxel was approved to use in chemotherapy. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Discovery and development of tubulin inhibitors」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.